منابع مشابه
Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose.
I T seems implausible that an injection of a simple, off-theshelf, intravenous nutritional solution could be acutely life-saving for a patient with severe drug overdose. But dozens of published case reports support this observation, first made more than a decade ago in a rodent model of bupivacaine toxicity. It is even more surprising that such a simple formulation can rapidly reverse severe cl...
متن کاملShould we consider the infusion of lipid emulsion in the resuscitation of poisoned patients?
The use of intravenous lipid emulsions (ILEs) as antidote in local anaesthetic systemic toxicity has gained widespread support following convincing data from animal models, and successful case reports in humans. Proposed beneficial mechanisms of action for ILEs include intravascular sequestration of intoxicant and subsequent enhanced redistribution to biologically inert tissues, augmentation of...
متن کاملInfusion of a lipid emulsion to treat lidocaine intoxication in a cat.
CASE DESCRIPTION A 5-year-old castrated male domestic shorthair cat was examined because of presumptive lidocaine intoxication. Thirty minutes earlier, the cat had received an SC injection of approximately 140 mg of lidocaine hydrochloride (20 mg/kg [9.1 mg/lb]) to facilitate closure of a wound on the left pelvic limb. CLINICAL FINDINGS Initial physical examination revealed severe lethargy an...
متن کاملHemodynamic changes with high infusion rates of lipid emulsion. Experimental study in swine.
PURPOSE To evaluate hemodynamic changes caused by sole intravenous infusion of lipid emulsion with doses recommended for treatment of drug-related toxicity. METHODS Large White pigs underwent general anesthesia, tracheal intubation was performed, and mechanical ventilation was instituted. Hemodynamic variables were recorded using invasive blood pressure and pulmonary artery catheterization. B...
متن کاملSudden Deaths of Neonates Receiving Intravenous Infusion of Lipid Emulsion Contaminated with Citrobacter freundii
At an intensive care unit, four neonates died consecutively within 80 minutes. Citrobacter freundii was isolated from blood samples of the 4 patients. It was also cultured from the leftover SMOFlipid that had been infused intravenously into the patients. In this in vitro study, we evaluated the bacterial growth kinetics and change in size of fat globules in SMOFlipid contaminated with C. freund...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2012
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e31825ad8de